<Influence of aldehyde dehydrogenase 1 expression on the clinical outcomes in breast cancer>

<Cancer Cell & Microenvironment 2014; 1 : e364. doi: 10.14800/ccm.364; © 2014 by Yoon Seok Kim> 

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Yoon Seok Kim (김윤석)

Department of Surgery, Kosin University Gospel Hospital, Busan 602-702, Korea

Breast cancer is a very heterogeneous neoplasm characterized by various molecular and clinical peculiarity. There has been several studies about ALDH1 cells which has the ability to form breast tumors. However, there is still controversy about these findings. However, as there are still controversies, verification of these findings are needed.
Recently, the author evaluated the relationship between the prevalence of ALDH1 tumor cells and their prognostic value in breast cancer patients. The study analyzed the association of survival outcomes with molecular subtypes of breast cancer with ALDH1 status. The result of this study showed that ALDH1 expression was related with worse survival outcomes as well as higher incidence of triple negative breast cancer. Our findings suggest that ALDH1+ expression is related with poor prognostic features and contribute to aggressive natures.

Keywords
Breast neoplasms; Neoplastic stem cells; Aldehyde dehydrogenase